I would play it safe and take a cab, especially if you have luggage. It looks like it is about 8 blocks, and I think the area around the hotel is fairly safe, but I'm not familiar with what is between there and the station. Often, people walking with luggage might as well have a sign on them that says " I don't live here, I'm vulnerable, rob me."
I've been to NOLA a couple of times post Katrina (once this year) and haven't had a problem, (wife and I have walked around in safe areas) but there are still some areas where it is safe on one block, and a block or two over, not so much.
Just my two cents worth.