Jim, as someone who has lived in Kfalls and currently lives near Medford, getting off in Eugene and driving down would be your best bet. The car rental agencies in Kfalls are at the airport, which is not very close to the train station. And highway 140 from Kfalls to Medford is pretty during the day, but it is also a trecharous 2 lane, mountanous highway, full of people who think they are driving on an Expressway. The drive from Eugene to Medford is only about 2 to 2 1/2 hours long. You will be going over several mountain passes when you get down to southern Oregon, but since you will be on a 4 lane intersate it is not bad at all. And if you like to gamble there is a casino just south of Roseburg, in Canyonville than can be a nice way to break up the drive.