My only stay in LoDo (the once run down and now trendy Lower Downtown area of Denver near Union Station) was at the Oxford Hotel.
Depending upon how much money you want to spend, and whether you are just looking for a comfortable room or something more, the Oxford Hotel falls squarely in the something more, but at a price, category. It is located on 17th Street about one block from Union Station. It is a superbly restored hotel, over 110 years old, and offers rooms decorated with period furnishing. Extremely comfortable, very friendly, and service is great.
The one time I stayed there, my wife, two kids and I were taking the California Zephyr from Denver to San Francisco (my one and only take the entire family overnight train ride). As we were leaving with our ton of luggage, the bellhop put our bags on the brass hotel luggage cart and wheeled it down 17th Street and right in the Amtrak baggage room. We felt like celebrities.
Now for the bad news. Rates are about $200 per night (and up).
Here is a web link to the
Oxford Hotel.